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Hypothyroidism , often called under active thyroid, is a common endocrine disorder in which the thyroid gland does not produce enough thyroid hormone. It can cause a number of symptoms, such as tiredness, poor ability to tolerate cold, and weight gain.

Hypothyroidism is caused either by inadequate function of the gland itself (primary hypothyroidism) or by not enough stimulation by thyroid-stimulating hormone (central hypothyroidism).Primary hypothyroidism is about a thousand fold more common than central hypothyroidism.